API – Dolutegravir

Intermediate CAS no. MF and M wt. Chemical Structure
(S)-7-hydroxy-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 1246616-73-8 C13H14N2O6 294.264
dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 1246616-66-9 C16H14O7 318.283
(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzyloxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido-[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide 1206102-11-5 C27H25F2N3O5 509.509
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid ethyl ester 1357289-04-3 C22H24N2O6 412.442
(R)-3-amino-1-butanol 61477-40-5 C4H11NO 89.1374
1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester 1206102-07-9 C17H19NO6 333.341
(R)-3-aminobutanoic acid 3775-73-7 C4H9NO2 103.121
(3R)-3-aminobutanoic acid; hydrochloride 58610-42-7 C4H10ClNO2 139.579
2,4-Difluoro-benzylamine 72235-52-0 C7H7F2N 143.136
1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid 1335210-23-5 C13H17NO8 315.28
Methyl-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-Methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate 1616340-68-1 C20H22F2N2O7 440.401
5-benzyloxy-4-hydroxy-6-methyl-nicotinic acid methyl ester 906657-87-2 C15H15NO4 273.288
5-(benzyloxy)-4-hydroxy-6-(hydroxymethyl)nicotinic acid 906657-91-8 C14H13NO5 275.26
(4R,12aS)-N-(2,4-difluorobenzyl)-7-methyloxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido [1′,2′,:4,5]pyrazino[2,1-b] [1,3]oxazine-9-carboxamide 1335210-35-9 C21H21F2N3O5 433.412
(4R,12aS)-7-(benzyloxy)-9-bromo-4-Methyl-3,4-dihydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-6,8(12H,12aH)-dione 1206102-10-4 C19H19BrN2O4 419.275
2,5-dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate 1357289-08-7 C20H23NO8 405.405
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 1339879-91-2 C20H20N2O6 384.389
1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester 1229006-21-6 C26H26F2N2O7  516.498